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They do not imply clinical relevance or therapeutic application

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Kidney Int 11(6):453465 Miller SG, Schwartz GJ (1997) Hyperammonemia with distal renal tubular acidosis

Curiously, inactivation of NgR-class receptors in the immune system, particularly CD4+ T cells, showed no effect, which may suggest that Nogo-A plays a minor role in peripheral cell activity, or that it may be almost fully dependent on a non-canonical receptor

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Cell line culture Human bladder carcinoma epithelial cells, designated 5637 (ATCC HTB-9) cells, were cultured in RPMI-1640 medium containing 10% FBS at 37 C in the presence of 5% CO 2