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The Interplay Between Oxidative Stress and Lipid Composition in Obesity-Induced Inflammation: Antioxidants as Therapeutic Agents in Metabolic Diseases

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They showed that semaglutide enhanced histological parameters of fibrosis and inflammation while decreasing hepatic expression of genes associated with fibrotic and inflammatory cascade: through proteomic profiling of serum from MASH patients treated with semaglutide, they detected 72 proteins linked to disease resolution and validated these findings in preclinical mouse models and an independent patient cohort [28]

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