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Fatigue In those without a vitamin B12 deficiency, there is little indication in the medical literature that B12 supplementation can improve fatigue symptoms

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[52] Biosynthesis [edit] GABA is primarily synthesized from glutamate via the enzyme glutamate decarboxylase (GAD) with pyridoxal phosphate (the active form of vitamin B6) as a cofactor

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Evidence remains mixed and often limited to small trials or animal models

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