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GLP-1 is quickly degraded by the dipeptidyl peptidase 4 (DPP-4) enzyme, making the plasma half-life 1-2 minutes

J Alzheimers Dis (2012) 28:19.10.3233/JAD-2011-111034 45 SchneiderJAArvanitakisZBangWBennettDA

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During the critical dose-escalation phase, we mandate GFR monitoring every four weeks to detect any subtle shifts in renal filtration efficiency before they become symptomatic