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In cultured adipocytes and several mouse models, 5-Amino-1MQ reduced the NNMT activity marker 1-methylnicotinamide and was associated with changes in adiposity, glucose handling, liver histology and aged-muscle performance

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Pyridoxine is recommended for B6-deficiency anemia, arthritis, muscle weakness, depression, hair loss

Depo-Medrol has the same side effect profile as other corticosteroids, plus some local effects from injection

Normally even high dose B6 complexes are not allowed to provide B6 over 25mg, which is the tolerable upper limit

Regarding FDA approval: because this is a compounded product, it is not directly FDA-approved