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Kuczynski J, Stombaugh J, Walters WA, Gonzalez A, Caporaso JG, Knight R

Finally, it is crucial to explore the key enzymes involved in CAT production by gut microbiota metabolism and their regulatory factors, evaluate the therapeutic potential of engineered probiotics (e.g., CAT-synthesizing strains) or exogenous CAT delivery systems (e.g., cartilage-targeted nanocarriers) for OA, and provide multi-level evidence for CAT-targeted OA therapy based on the gut-joint axis

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2006, doi: 10.1113/jphysiol.2006.113936

Administered directly into the bloodstream, this treatment improves absorption for maximum effectiveness

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