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9 Multiple modalities, including lifestyle modification, mechanical gastric restriction, modulation in the secretion of multiple gut hormones, alteration in the composition and secretion of bile acids, and alterations of the gut microbiome, have been explored in obesity management

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More critically, it restores impaired autophagic flux, effects that are closely linked to its ability to preserve NO metabolic homeostasis ( Figure 3c ) (80)

10.1021/jm025522z 46