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A clear improvement of ataxia by 44% and 20% was observed in two patients, respectively, as measured by the ICARS score, an objective assessment that quantifies the magnitude of improvement in progressive ataxias, with a score of 5%-20% considered as substantial in providing a clinical impact

However, TREK-1 knockout mice are viable and generally healthy, suggesting that complete loss of TREK-1 function is tolerated

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Most studies have used in vitro exposure to a single, relatively high dose of environmental toxins, which is very different from the actual exposure of humans to the environment, which is usually a mixture of multiple pollutants in chronic low doses