After two months, even perfectly stored compounded semaglutide may have lost enough potency to reduce effectiveness
In clinical trials for type 2 diabetes (SURPASS), nausea was reported by approximately 12-29% of patients receiving tirzepatide, depending on the dose, compared to 6-8% receiving placebo
Semaglutide is found in other popular weight loss medications, including Ozempic, but Wegovy contains higher doses
Both groups were instructed to take the medicine along with a reduced-calorie meal plan and increased physical activity
Regarding the regulatory environment: while the tirzepatide and semaglutide shortages have resolved, Empower maintains that 503A pharmacies may still compound these drugs if they meet clinical difference criteria under Section 503A of the Federal Food, Drug & Cosmetic Act
The patience required during tirzepatide titration pays dividends in the months that follow