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GIP (glucose-dependent insulinotropic polypeptide) drives glucose-dependent insulin secretion from pancreatic beta cells and modulates adipose tissue lipid handling

Retatrutide achieved approximately 24 to 28.7% weight loss at its highest dose over 48 to 72 weeks, compared to Mounjaro achieving approximately 20 to 22.5% at its highest dose over 72 weeks

10.1095/biolreprod.114.119032 16 HauserR.GaskinsA

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Over the past decade, CVOTs in this class have evolved from primarily assessing safety in patients with type 2 diabetes mellitus (T2DM) to demonstrating broader cardioprotective advantages, including in non-diabetic individuals with obesity [43]