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By blocking NF-B, it reduces the production of pro-inflammatory cytokines (IL-1, TNF-, IL-6) and inflammatory mediators (PGE2, NO) in keratinocytes and dermal cells

Methylmalonyl-CoA Mutase: B12 participates in the conversion of methylmalonyl-CoA to succinyl-CoA, linking certain fatty acid and amino acid degradation pathways into the tricarboxylic acid (TCA) cycle

These medications can deliver dramatic results without the risks, recovery time, or lifelong changes associated with surgical intervention

If persistent vomiting or diarrhea prevents adequate oral hydration, intravenous fluid replacement may be necessary

Rippe, J

doi:10.1002/dta.2152