retatrutide phase 3 2025 triple agonist glp-1 gip glucagon Lilly's achieves 16.8% weight loss in trial Today, we shared new data

The early data is compelling enough to take seriously, but its not settled

Stay ahead on fluids

Detoxification of trichothecene mycotoxins by a novel bacterium, Eggerthella sp

Among all adults, 7% say they have taken or are taking these drugs to treat a chronic condition such as diabetes or heart disease either alone (5%) or in combination with intent of losing weight (3%) while 5% of adults report ever taking these drugs to lose weight but not to treat a chronic condition

What makes this combination distinct from single-peptide studies

In the ischemia-reperfusion (I/R)-AKI model, the E3 ligase Trim21 is highly expressed, which modulates AKI by ubiquitinating degradation of glutathione peroxidase 4 (GPX4)