Standard pharmacological approaches suppress that cytokine output directly (TNF- inhibitors, corticosteroids)
Funding This work was supported by JST CREST Grant Number JPMJCR2024 (20348438 to T.A.), a Grant-in-Aid for Challenging Exploratory Research (22K19397 to T.A.), a Grant-in-Aid for Scientific Research on Innovative Areas (A) Sulfur biology (21H05263 to T.A., 21H05267 to T.S., and 21H05258 to T.A
Acetyl-L-carnitine is an orally active mitochondrial energy metabolism regulator and neuroprotectant that can penetrate the blood-brain barrier
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The cryoprobe is applied directly or immediately adjacent to the peripheral nerve of interest and creates localized freezing which induces axonotmesis in which Wallerian degeneration of the axon and myelin sheath occurs distal, and to a lesser extent proximal, to the lesion [19]
