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Furthermore, compared to the F1 group, there was a significant decrease in BDNF levels in the F2 group in all brain areas tested except thalamus and hypothalamus (midbrain: ( p = 0.02)

doi: 10.1161/CIRCRESAHA.119.315939 138 ZhangXHouLGuoZWangGXuJZhengZet al

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10.3748/wjg.v22.i7.2219 World J

In addition to monitoring weight loss and nutritional statues, future clinical trials should measure nausea and emesis following activation of central GLP-1-producing circuits as these adverse effects are the main reason cited for discontinuation of GLP-1R agonist pharmacotherapy 29,39