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Sphingolipid metabolites, such as sphingosine 1-phosphate, play a crucial role in the modulation of inflammatory diseases ( Furthermore, we observed that the level of spermidine was higher in the plasma of patients with MS than in healthy controls

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Findings may not be generalizable to other payor populations due to the study sample consisting primarily of commercially insured patients in the US

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In addition, there are also a number of therapeutic approaches using the natural product extracts after APAP administration with significant amelioration of the liver function and improved survival ( Table 2 )