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Bibcode:2013JBiCh.28826480L

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The amygdala, the hippocampus and the hypothalamus are the brain regions with the highest concentration of vitamin C, but even in these structures the distribution is not homogeneous (Mefford et al., substantia nigra is the brain region with the lowest concentration of ascorbate (Grmewald, Vitamin C and neuronal differentiation, maturation, and survival The effect of ascorbate on the differentiation of embryonic stem cells into neurons in vitro is associated with an increase in the expression of genes involved in this process (Harrison and May, in vitro due to the potentiating effect of 2-glucoside-L-ascorbic acid (ascorbate analog) on the nerve growth factor (NGF) has also been shown