Research has shown that CA extract and its bioactive compounds, such as asiatic acid and asiaticoside, possess antihyperlipidemic properties by reducing plasma glucose, triglyceride, and total cholesterol levels [61]
The gpoA, tpxD, ahpD , and gshT mutants exhibited increased susceptibility to H 2 O 2 , and also impaired intracellular survival in pneumocytes, macrophages, and neutrophils compared to the wild-type strain
In addition, according to relevant studies, dietary polyphenols are bio-transformed by the liver and intestines, and their metabolized derivatives have certain biological activities, which will be described in detail below 55,56
*Correspondence: Xuezhong Gong, [email protected] This article was submitted to Renal Pharmacology, a section of the journal Frontiers in Pharmacology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers
Preclinical support for the potential of these drugs to alleviate IR damage has been shown for SOD@ARA290-HBc in RILI and for pMnSOD in radiation-damaged keratinocytes, demonstrating the translational potential for both of these antioxidant therapeutics [69, 77]
Oral options depend entirely on how well theyre absorbed, not just the ingredient itself
