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JAMA 2025;333:1062-73.ArticlePubMedPMC 136

Ahuja AS et al

Results reveal your genetic predispositions across 14 metabolic pathways, allowing PlexusDx to tailor your calorie target and nutrition plan

Wulffel M.G ., Kooy A., De Zeeuw D., Stehouwer C.D.A., Gansevoort R.T.: The effect of metformin on blood pressure, plasma cholesterol and triglycerides in type 2 diabetes mellitus: A systematic review

Sequential initiationadding one agent, allowing 48 weeks for tolerance to develop, then introducing the secondmay improve tolerability, particularly regarding gastrointestinal side effects from GLP-1 receptor agonists

This finding is particularly significant as it demonstrates that the cardiovascular benefits of GLP-1 agonists extend beyond their glucose-lowering effects to encompass direct cardiovascular protection in obesity