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For many individuals, GLP-1 therapy can finally make weight loss feel achievable after years of frustration with restrictive diets and short-term solutions

Mooney can speak to this too

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[See Dosage and Administration (2.2).] Hepatic Insufficiency In patients with moderate hepatic insufficiency (Child-Pugh score 7 to 9), mean AUC and Cmax of sitagliptin increased approximately 21% and 13%, respectively, compared to healthy matched controls following administration of a single 100 mg dose of Januvia

It may seem contradictory that both diarrhoea and constipation appear on the side effect list, but this reflects the variability in individual responses to slowed gastric emptying

Potential Side Effects and Considerations Semaglutide, like other medications, can have side effects