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Lanosterol then undergoes further enzymatic modifications via the Bloch pathway, the Kandutsch-Russell pathway or a hybrid of both, ultimately resulting in cholesterol ( On the other hand, enterocytes absorb dietary cholesterol from the intestinal lumen through a process involving the cholesterol transporter Niemann-Pick C1-like protein 1 (NPC1L1)

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Food texture, temperature, and composition can significantly influence tolerance

These results would allow taking the decision to either stop or continue the treatment as early as 12 weeks after the start of therapy