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Seek medical advice if gastrointestinal symptoms significantly impact your quality of life or prevent you from maintaining adequate nutrition and hydration

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doi: 10.1038/s41592-021-01197-1 12 JinQMaRCW

After 4 weeks, increase the dose to 0.5 mg once weekly

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The efficacy of liraglutide on weight management was subsequently surpassed by semaglutide, which, when administered weekly at a dose of 2.4 mg in obese patients without diabetes, resulted in a weight reduction of 12.4% compared to placebo in the STEP 1 study [46], and a reduction of 9.4% compared to liraglutide 3.0 mg in the STEP-8 study [47]