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While some experimental studies show promising results, this potential benefit remains under investigation

A 2025 study in Biomolecules found that NNMT inhibitor treatment "reduces body weight, white adipose tissue mass, total cholesterol, and adipocyte size in obese mice." These changes suggest cardiovascular benefit beyond simple weight loss

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Network meta-analysis of 6,213 patients revealed that semaglutide 2.0mg delivered the strongest glucose-lowering effect at -1.74% HbA1c reduction and -5.51 kg weight loss

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