The most frequently reported adverse events (AEs) of GLP-1 RAs were gastrointestinal adverse drug reactions, including nausea, vomiting, and abdominal pain, which were closely related to activation of central and peripheral GLP-1 receptors ( In a recent network meta-analysis, overall GLP-1 RAs significantly increased the incidence of gastrointestinal AEs compared with placebo or conventional treatment, and the odds ratios for nausea, vomiting and diarrhea from GLP-1 RAs were 11.8 (95% CI, 2.8946.9), 51.7 (95% CI, 7.07415), and 4.93 (95% CI, 1.7514.7), respectively ( Methods Data sources This retrospective pharmacovigilance study was conducted based on the FDA Adverse Event Reporting System (FAERS) database
Limited safety and efficacy data for research peptides creates uncertainty about their appropriate use and potential risks
Diabetes 64, 25132525
& Hallam, T
Nammi D, Srimath-Tirumala-Peddinti RCPK, Neelapu NRR (2016) Identification of drug targets in Helicobacter pylori by in silico analysis: possible therapeutic implications for gastric cancer
Japan Patent Application JP2011234645 (A) Townsend DM, Tew KD, Tapiero H (2003) The importance of glutathione in human disease