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Clinical practice guidelines suggest several scenarios where dose modification may be appropriate: Persistent gastrointestinal symptoms lasting beyond the first week of a new dose level may warrant extending that dose phase by an additional 2-4 weeks before further escalation

Thirdly, long-term observational studies are becoming increasingly critical

It was discovered that the lactate and butyrate-producing bacteria in the control group were responsible for the production of mucin, which is essential for maintaining gut integrity

[DOI] [PubMed] [Google Scholar] 44.Peters M.D.J., Godfrey C.M., Khalil H., McInerney P., Parker D., Soares C.B

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When treatment stops, some weight may come back, but many people still keep off more than they would without it