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Tat leads to neuronal death by activating calcium release from IP3-sensitive intracellular pools, causing endolysosomal dysfunction and dendritic impairments, which ultimately contribute to spatial memory impairment and premature brain aging [154,155,156,157,158]

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According to Good Life Family Medicine, semaglutide is the first FDA-approved drug since 2014 for chronic weight management in overweight or obese adults

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The FDA has received adverse-event reports involving compounded semaglutide and tirzepatide, including dosing errors and events requiring medical attention