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Reported side effects Mild headache or fatigue typically transient during initial use Mild gastrointestinal discomfort reported in some oral formulation users Sleep disruption or irritability potential sign of overstimulation Theoretical safety concerns Critical note: Because Dihexa activates the HGF/c-Met pathway which promotes cellular growth and repair there is a theoretical concern that it could potentially stimulate unwanted cell proliferation in individuals with active cancer or high cancer risk

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In an in vitro lipopolysaccharide-induced microglial activation model, sevoflurane reduced microglial activation by suppressing NF-B and MAPK signaling [30]

Pemetrexed Injection: Package Insert / Prescribing Info Package insert / product label Generic name: pemetrexed disodium Dosage form: injection, solution Drug class: Antimetabolites J Code (medical billing code): J9304 (10 mg, injection) Medically reviewed by Drugs.com