However, the association between MTHFD2L, which can use either NAD + or NADP + for dehydrogenase activity, and tumors remains to be investigated
Common side effects (10% incidence) observed in trials included injection-site reactions (redness, pain), headache, diarrhea, and fatigue [pubmed.ncbi.nlm.nih.gov]
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However, Phase 1b/2a results in 125 patients must be confirmed in large Phase 3 trials