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Semaglutide is a groundbreaking, FDA-approved medication that helps regulate appetite, control cravings, and support long-term weight loss

In the regulation of feeding behavior, GLP-1 neurons project to brain regions such as the ARC and the paraventricular nucleus (PVN) to exert their effects

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## Efficacy: Weight Loss Results Comparison ### Phase 2 and Phase 3 Data for Orforglipron The orforglipron Phase 2 trial, published in *Nature Medicine*, randomized 272 adults with obesity to orforglipron (12 mg, 24 mg, 36 mg, or 48 mg daily) or placebo over 36 weeks

OA-J: Investigation, Writing original draft, Writing review & editing