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In this case, the mechanism of down-regulation is linked to promoter methylation (Scalise et al., 2012
[Abstract]2025 Sep 4;242(Pt 2):117306
However, for some individuals with residual absorption capabilities, high-dose oral supplements can serve as an alternative
A.GheorgheG.HlescuA
By disrupting the interaction between FOXO4 and p53, FOXO4-DRI induces apoptosis (programmed cell death) in senescent cells, reducing their harmful effects
52 Cellular stress, such as DNA damage, hypoxia, and oncogene activation, disturbs the interaction between p53 and MDM2 and inhibits p53 degradation, resulting in p53 accumulation
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