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Updated September 15, 2025

Anti-inflammatory effects of GLP-1 medicines independent of weight loss Several GLP-1 medicines, including semaglutide, liraglutide, and exenatide, reduce plasma levels of C-reactive protein (CRP), a surrogate of systemic inflammation, in people with obesity or T2D

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Arajo F, Fonte P, Santos HA, Sarmento B

They enhance glucose-dependent insulin secretion , meaning the body is better able to release insulin when blood sugar rises

The loss of sirtuin 6 (SIRT6), which regulates proinflammatory mediators, in human umbilical vein endothelial cells is associated with upregulation of the expression of proinflammatory genes [71]