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During maturation, the propeptide is cleaved by the proprotein convertase furin to generate the mature form of LEAP2, a 40-amino-acid bicyclic peptide (corresponding to residues 3877) containing two disulfide bridges and exhibiting both antimicrobial and metabolic activities [22, 45]
The increase in potential exposure in recent years is apparent from our study, in which, among a broader cohort of more than 2.1 million pregnancies, the prevalence of GLP-1 dispensing in the 90 days prior to the last menstrual period and conception increased from 2 per 1,000 in 2020 to 15 per 1,000 in 2024, Brown explained
GLP-1s can even make treats like fried foods or sweets seem less delicious
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