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GST is able specifically to bind to GSH or GSH analogs via the G-site, which catalyzes the interaction between GST amino-acid residues with GSH sulfhydryl and conventional electrophilic substances at the H-sites to promote catalytic action

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An impressive 45.8% of patients taking NAC at doses greater than 600 mg/day reported significant positive clinical effects in managing their systemic fatigue and cognitive dysfunction