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2026 Jan 2;136(1):e196346

Tofacitinib, a selective JAK1/JAK3 inhibitor that prevents STAT3 phosphorylation and activation, has been approved for UC treatment [95]

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ME/CFS lacks standardised diagnostic criteria owing to variations in both inclusion and exclusion criteria across different diagnostic guidelines, and furthermore, there are currently no effective treatments available

She adds another explanation for why some individuals might seem to observe this association: Weight gain is also linked to the perimenopausal and post-menopausal state, and a GLP-1 is a reasonable treatment for this for those who qualify. What this means is that for some women, the weight loss effects of a GLP-1 and the symptoms of low estrogen may occur at the same time, making it difficult to tell whether the changes are due to the medication, hormonal shifts, or both