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Without the medication, people with insulin resistance or type 2 diabetes often see fasting glucose and HbA1c climb back toward pre-treatment levels

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Additionally, thermosensitive nanogels and stimuli-responsive nanocarriers that respond to pH or glucose levels have been proposed for precision-controlled GLP-1 delivery, enabling intelligent drug release based on glycemic fluctuations

We expect phase 2 data from the lead AMG133 program in the second half of 2024

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