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This connection has opened to a potential new strategy, in which new classes of anti-diabetic medications, such as glucagon-like peptide-1 receptor (GLP-1R) agonists and sodium-glucose cotransporter 2 (SGLT2) inhibitors, are able to reduce the overall risk of cardiovascular events and neuronal damage, showing additional protective effects beyond glycemic control

The primary sensory neurons of the vagal afferents are located in the bilateral nodose ganglia (NG) that relay peripheral nerve signals from the gastrointestinal tract to the nucleus tractus solitarius (NTS) in the medulla oblongata

Finally, adding the mtDNA as a single gene produces our list of 22 genes that we propose that are at least Likely related to CVS (Table 4)

The interesting part over the next 1218 months will be watching who can scale repeatably without creating compliance drift, turnaround delays, or variability across sites