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Based on researcher community reports, the most commonly noted adverse effects are injection site reactions (redness, minor discomfort), mild nausea particularly with oral administration, and occasional transient dizziness or headache

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Additionally, granulosa cells in women with endometriosis exhibit apoptosis, mitochondrial dysfunction, disrupted steroid hormone production, and increased inflammatory markers, further compromising follicle health ( These changes contribute to significant oocyte quality defects

333 The KARDIA-2 study further demonstrated that zilebesiran, when added to standard antihypertensive therapy, achieved an additional reduction of 412 mmHg in the mean SBP without any new safety concerns

Moreover, continuous pharmaceutical innovation and favorable healthcare reimbursement policies are further contributing to market growth across Japan