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The inhibition of LOX enzymes, especially 5-LOX, has shown promise as a therapy for anti-inflammatory and anti-cancer effects

These are typified by the following two enzymes: Methylmalonyl-CoA mutase [edit] Methylmalonyl coenzyme A mutase (MUT) is an isomerase enzyme that uses the AdoB 12 form and reaction type 1 to convert L-methylmalonyl-CoA to succinyl-CoA, an important step in the catabolic breakdown of some amino acids into succinyl-CoA, which then enters energy production via the citric acid cycle

Still, the majority of European countries, for example, have imposed very strict utilization controls, generally limiting use to patients with high body mass index

Campbell JE

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JANUMET XR is contraindicated in severe renal impairment, patients with an eGFR below 30 mL/min/1.73 m2