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Growing evidence suggests that retinal neurodegeneration is an early event in the pathogenesis of DR [11]

Copper is an essential trace element, but excess copper is toxic

doi: 10.1158/0008-5472.CAN-18-2545 55 DineenSPLynnKDHollowaySEMillerAFSullivanJPShamesDSet al

Furthermore, arginine helps fish detoxify ammonia through the urea cycle, which is particularly important during stress when protein breakdown is accelerated [91]

Toxicol Lett 144:279288 James O, Lesna M, Roberts SH, Pulman L, Douglas AP, Smith PA, Watson AJ (1975) Liver damage after paracetamol overdose

Structural analysis The interface area was calculated by FreeSASA 53 using the Sharke-Rupley algorithm with a probe radius of 1.2