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Glutamate and Gamma-Aminobutyric Acid Systems in the Pathophysiology of Major Depression and Antidepressant Response to Ketamine

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The review is timely, as a number of primary reports shed exciting new insights into the role of the hypothalamus in regulating novel aspects of metabolic homeostasis including fatty liver disease. Abels next paper, Obesity disrupts the pituitary-hepatic UPR communication leading to NAFLD progression , homes in on this mechanism

Everyone inherits one of three forms (alleles) of the APOE genee2, e3 or e4from each parent, resulting in six possible APOE pairs: e2/e2, e2/e3, e2/e4, e3/e3, e3/e4 and e4/e4

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