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Therefore, we believe that the Prescriber-Pharmacy Methodology as described in this final rule, which incorporates enhancements to address identified limitations such as in-house pharmacies, as recommended by commenters, represents an appropriate accounting of 340B units to remove in calculation of a manufacturer's inflation rebate liability

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[2] Heffernan, M., Summers, R

Another two-year study of 500 type 2 diabetes patients showed 15% experienced decreased B12 levels, with 5% developing outright deficiency

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