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A Penn State study found decreased opioid cravings in patients with that disorder who took the active ingredient in the GLP-1 drug Saxenda

Excess body weight puts stress on the joints, increasing risk of fractures, but weight loss from calorie restriction is associated with reductions in bone mineral density (BMD) with increased bone turnover

Charbonnel B, Karasik A, Liu J, et al

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Androgen metabolism via 17-hydroxysteroid dehydrogenase type 3 in mammalian and non-mammalian vertebrates: comparison of the human and the zebrafish enzyme