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Based on data from the SOUL clinical trial, Novo Nordisk submitted a label extension application for Rybelsus (semaglutide) tablets 14 mg which has been accepted for review by the FDA

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Q4: Can I start Hormone Replacement Therapy (HRT) while I am on Semaglutide

If you use insulin (any type), close monitoring is important, and your insulin dose may need reduction over time

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As stated in MHRA guidance, this is allowed in clinical situations when the use of unlicensed medicines or use of licensed medicines outside the terms of the licence (i.e