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Concerns about unapproved GLP-1 drugs

Nutrients , 13 (12), 4359

Most cytokines and their receptors are expressed by neurons and glial cells throughout development, and several studies have revealed that cytokines play important roles in neurogenesis, synapse formation, and plasticity, including IL-1, IL-6, TNF-, TGF-1 and IFN 326,327,328,329,330,331 Cytokines activate several signal transduction pathways, including the Janus kinase-signal transducer and activation of transcription (JAK-STAT) and PI3K/AKT/mTOR pathways, which regulate numerous cellular responses

In their lyophilized state, peptides are stable but inactive

For example, in the tirzepatide study mentioned, 1.7% of placebo recipients reported vomiting compared to 8.3% of those taking 5mg doses, 10.7% of those taking 10mg doses, and 12.2% taking 15mg doses

Salsalate has been used for many years to treat pain and inflammation in arthritis, and was recently shown to lower hemoglobin A1C (HbA1C) and markers of inflammation in patients with inadequately controlled type 2 diabetes