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4.1.1 BCL family inhibitors The BCL family consists of proteins such as BCL-2, BCL-XL, and MCL-1, serving both proapoptotic and pro-survival functions [101]

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doi: 10.1016/s0026-0495(76)80002-9

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The combination protocol increases the number of dose escalation events (since you are titrating two compounds), which may mean more frequent but generally mild headaches