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Such investigative approaches not only help to accelerate discovery of novel variants for diagnosis but also aid in the study of disease susceptibility and expansion of the panel for future genetic testing

Consequently, it is anticipated that under normal physiological situations, ER set up a source of ROS in living cells, and the flow of electrons from reduced sulfhydryl to Pdi1p/Ero1p would be reflected in which the amount of ROS generated (Park et al., 2018) (Fig