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Various factors can trigger GERD, including: A hiatal hernia that weakens the lower esophageal sphincter (LES), the valve preventing stomach acid backflow Obesity, pregnancy, or restrictive clothing that increases abdominal pressure Smoking, alcohol, caffeine, chocolate, spicy or fatty foods, citrus, tomatoes, mint, garlic, onions, and other items that relax the LES or stimulate acid production Certain medications including aspirin, ibuprofen, naproxen, steroids, antihistamines, antidepressants, calcium channel blockers, or nitrates Stress or anxiety affecting digestive processes or acid production The COPD-GERD Relationship Though COPD and GERD are distinct conditions, they share several interconnections

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We aimed to discover novel metabolic vulnerabilities that could be exploited therapeutically

doi: 10.4049/jimmunol.181.7.4883 46 OMalleyYQReszkaKJSpitzDRDenningGMBritiganBE

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But individual responses vary, and monitoring is appropriate