GLP-1 has a plasma half-life of a few minutes due to proteolytic degradation by the serine protease, dipeptidyl peptidase-IV (DPP-IV), which cleaves the N-terminal histidine and alanine residues from GLP-1 to generate GLP-1 937 and GLP-1 936 amide
Ozempic (semaglutide), a GLP-1 receptor agonist originally approved for type 2 diabetes, has become one of the most widely prescribed drugs for weight loss in the United States
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Contact your healthcare provider if the diarrhea is severe or does not subside
They may be able to adjust timing, reduce dosages, or eliminate medications that are no longer necessary as tirzepatide takes effect
Phytomedicine: International Journal of Phytotherapy and Phytopharmacology