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In brief, NRF2 detaches from Kelch-like ECH-associated protein 1 and translocates to the nucleus, where it activates the expression of downstream target genes containing antioxidant responsive elements

doi: 10.1126/science.284.5421.1835 88 ShiYEvansJERockKL

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Then cumulative food and water intake for the following 0.5, 1, 2, 3, 6, and 24 h was measured by subtracting uneaten food/water from initially premeasured food/water after administration and checking the food spillage

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