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6e) showed that APP/PS1 mice treated with ITP-LNP/siBACE1 and the WT (saline-treated) mice could repeatedly find the platform in the target quadrant, and the number of platform crossings, the length of the platform, and the length of the target quadrant were significantly greater than those of the mice given LNP/siBACE1, ITP-LNP/siScr, or LNP/siScr

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A 2008 animal study looked at the benefits of MSM or combined MSM + vitamin C and found that supplementation with both led to more pronounced effects than MSM supplementation alone (6)

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The fraction of sitagliptin reversibly bound to plasma proteins is low (38%)