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Key findings: 12 mg dose: Average weight loss of 24.2% of body weight (approximately 58 lbs for a 240 lb individual) 8 mg dose: Average weight loss of 22.8% 4 mg dose: Average weight loss of 17.0% Placebo: Average weight loss of 2.1% Over 90% of participants receiving the 8 mg or 12 mg dose lost at least 10% of body weight Over 75% of participants at the highest dose lost at least 20% of body weight Significant improvements in waist circumference, blood pressure, and lipid profiles were observed across dose groups Phase 2 Trial in Type 2 Diabetes A separate phase 2 trial evaluated retatrutide in adults with type 2 diabetes and obesity (Rosenstock et al., Lancet , 2023)

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Dual and triple agonists Dual agonists with effects on GLP-1 receptors and glucose-dependent insulinotropic polypeptide receptors, like tirzepatide, and triple agonists with effects on GLP-1, glucose-dependent insulinotropic polypeptide, and glucagon receptors like retatrutide are currently being researched for their beneficial effects on obesity and diabetes in the adult population

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